Technology

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Innovative in-house vertically integrated solutions for science, research and industry

[/vc_column_text][/vc_column][vc_column width=”1/6″][/vc_column][/vc_row][vc_row][vc_column width=”1/6″][/vc_column][vc_column width=”2/3″][vc_column_text]SWISSCI is an innovative technology company serving the global scientific community with expert manufacturing and production processes. Based on plastic injection moulding innovation and excellence, we develop high quality specialty kits and filtration devices for clinical laboratories for research and routine diagnostics. Our highly polished steel moulds ensure best levels of optical quality. Our production areas are operated under clean-room conditions. We are certified and work in accordance with the international GMP standard. Our products are CE marked. We control the process of innovative design, tools, mould-making and manufacture and delivery of our products all under one roof. This helps us to maintain superior quality control and speed to market as we are not dependent on other suppliers. Our production areas operate under clean-room conditions.[/vc_column_text][/vc_column][vc_column width=”1/6″][/vc_column][/vc_row][vc_row][vc_column width=”1/6″][/vc_column][vc_column width=”2/3″][vc_separator color=”custom” style=”shadow” border_width=”5″ accent_color=”#ed1c24″][/vc_column][vc_column width=”1/6″][/vc_column][/vc_row][vc_row][vc_column width=”1/6″][/vc_column][vc_column width=”2/3″][vc_column_text]

CASE STUDY #1: MOULDING SOLUTIONS – MICROPLATES

SWISSCI offers novel plastic solutions. Our production areas are operated under clean-room conditions. SWISSCI is certified and works in accordance with the international GMP standard. Our products are CE marked.

Our microplate products fulfill the consistency, highest quality and finish demanded by the life science and diagnostic markets. These microplates are a cost-effective alternative to those currently available yet deliver the consistency and highest quality expected by the market.

The SWISSCI Microplate Product Range is available in a range of virgin polymers – proprietary Ultra Violet Transmissing (UVP), polystyrene, autoclavable polycarbonate and high-grade polypropylene. Only materials certified by the FDA (Food and Drug Administration, USA) are used for SWISSCI products.

Recycled materials, even from current production are strictly forbidden. Plates have a wide range of temperature and chemical resistance.

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SWISSCI owns a state-of-the-art automated gluing line with autonomous cleanroom cell.
Below is the automat, the gluing unit, and our planarity test system.

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Individual well labelling

Each well is alpha-numerically indexed for easy sample identification. Raised well rims that contribute to cross-contamination free results ensure uniform well-to-well performance by ensuring total sample integrity.

White and black Microplates for chemi-luminescence and fluorescence readings. Opaque white plates provide maximum reflection for luminescence measurements (for example in Luciferase Reporter Assays). Black microplates provide maximum sensitivities in fluorescence quantification (for example in Green Fluorescent Protein measurement)

Production and assembly in the clean room SWISSCI  produces in a class 100,000 clean room: microplates are robotically detached from the injection moulding point. All products are subject to a 100% release performance test checking, in addition, the precision of each batch to ensure continuity of supply. Using this approach removes the risk of particle contamination, oxidative degradation, plastic discoloration, and product brittleness.

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We own proprietary microplate types including Swiss quality moulds for our square-well bottomless plates
for gluing onto transparent bottoms on our proprietary gluing line.

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CASE STUDY #2: PRODUCT INNOVATION – CRYSTALHARP

Aims:

Develop capillary crystallization plate based on the counter-diffusion method

• Applicable for high throughput screening X-tal experiments

• Applicable for individually designed X-tal experiments

• Compatible with any incubation and imaging system

• Easy to work with (loading protein/ solutions, mounting of X-tals).

Solution: Crystalharp

• SBS formatted capillary plate designed for 48 counter diffusion X-tal experiments

• Manufactured and sold by SWISSCI[/vc_column_text][/vc_column][vc_column width=”1/6″][/vc_column][/vc_row][vc_row][vc_column width=”1/6″][/vc_column][vc_column width=”2/3″][vc_column_text]

CrystalHarp – Video User Guide

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CrystalHarp – Datasheet

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APPLICATIONS

High Throughput Screening

• Protein crystallisation
• Screening hybridoma cultures for antibody production
• High throughput screening of small scale expression systems for affinity tagged recombinant proteins
• Small scale screening of extraction, solubilization and cell lysis techniques for sample preparation  procedures
• High throughput screening of receptor-ligand binding studies and domain interaction analyses
• Screening of DNA libraries
• Screening compounds in combinatorial chemistry

Analyses

• Multiwell plates for immunoassays e.g. ELISA, RIA measurements
• Protein and nucleic acid concentration measurements
• Enhanced luminescence detection of low abundance proteins e.g. oncogene products, cell cycle proteins

Proteomics

• High throughput solution state and in-gel digestion of proteins
• High throughput sample preparation prior to mass spectrometry

Diagnostics

• Perfect carrier for broad range of human immunoassays
• High throughput sample preparation prior to reading in auto analyser

Metabolic Studies

• Metabolic transport studies
• Steady-state or pulse chase radiolabeling (35S) of bacterial cultures
• Radiolabeling (35S, 32P) of eukaryotic cells

Assays

• Solution and cell-based assay development
• Antibiotic screening serological tests
• Enzyme assays (Protease assays, signal transduction,kinase/phosphatase)
• Fluorescence-based cell assays (opaque white and black plates)
• Fluorescence correlation spectroscopy (opaque white and black plates)
• Luminescence-based cell assays (opaque white and black plates)

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In house Advanced Machinery

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Automated Gluing at SWISSCI Facilities

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CASE STUDY #3: IMAGING EXCELLENCE WITH FORMULATRIX AND SWISSCI 2-LENS UVXPO PLATES

SWISSCI and Formulatrix brought to market a new advancement in UV and cross-polarized imaging with the development of the UV Cross-Polarized (UVXPO) plate, which uses a specialized polymer mixture specifically designed to maximize UV and cross-polarized imaging.

Dr. Ellen Gualtieri of Formulatrix has tested the UVXPO plates with visible, cross-polarized, and UV light, and found a 75% reduction in plate auto-fluorescence when compared to other plates. This allows the user to more easily see protein crystals with weaker fluorescence because of the reduced background fluorescence.

The plate has been successful in trials at the University of Zurich in Switzerland using the Formulatrix Rock Imager, and is now available for demonstration at Formulatrix headquarters in Boston.

UVXPO plates can be purchased through Swissci and Swissci distributors. For further information please contact Swissci (sales@swissci.com) or Dr. Ellen Gualtieri, Imager Product Manager, Formulatrix (www.formulatrix.com).

To read the Formulatix guide on UV Fluorescence Imagining featuring our 2 Lens UVXPO Plate please go here.

For more information on the Forumlatrix Rock Imager please click here.

 

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Formulatrix Rock Imagers

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SWISSCI 2-Lens UVXPO Datasheet

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SWISSCI 3-Lens UVXPO Datasheet

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