PRODUCTS - SWISSCI

SWISSMX CM Supports

Crystallisation, Supports

SWISSCMX CM Supports are an innovative support for serial data collection from micro-crystals

The SWISSMX CM supports are designed for high throughput serial data collection from micro-crystals at synchrotrons and XFELS. SWISSMX CMs are designed and engineered by scientists of the Macromolecular Crystallography group and the Laboratory of Micro and Nanotechnology at the Paul Scherrer Institute in collaboration with the Institute of Polymer Nanotechnology at Fachhochschule Nordwestschweiz. The polymer-based ultra-thin porous membranes present users with an effective and accessible product for use at MX beamlines.

SWISSMX CM Supports Low Background Ultra Thin Porous Membranes

Amorphous COC (Cyclic Olefin Copolymer) for low X-ray scattering
Microfabricated film with imprinted perforations

Blotting Function

Easy deposition of drop-scale samples
Efficient blotting to minimize background
Hydrophilic surface properties help to retain a thin hydration film around the crystals

Designed to be used at cryogenic temperatures

Dimensions designed for fitting in standard (cryo)streams
Flash-cooling possible in cryojet or liquid nitrogen
Room temperature use possible: compatible with humidifying jets, enclosure possible

Extensive Compatibility

SPINE base or ALS style base
Compatible with Uni-puck and with SPINE pucks (cryovial)
Compatible with a number of sample changers including the new TELL at Swiss Light Source and SwissFEL SwissMX

Additional Benefits

High transparency for excellent visibility and imaging
Built-in 100 µm period scale

Link to a publication detailing the fabrication of SWISSMXCM Supports: https://www.sciencedirect.com/science/article/pii/S2590007220300083

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SWISSCI Plates: Improvements in Imaging with UVXPO

UVXPO, Crystallisation, Midi UVXPO

UVXPO: Our Most Advanced Polymer

SWISSCI crystallisation plates are available in 3 polymers. Polystyrene (PS) is a cost-effective polymer that Is optically clear when using standard bright field or visible light sources. However, when imaging drops using both cross polarised (XP) and UV light, the quality of the image is impaired by the interaction of the polymer with the light source.

SWISSCI’s UVP polymer has been designed to reduce the auto-fluorescence coming from the plate, improving the UV image quality.

SWISSCI’s UVXPO polymer also has the same low auto-fluorescence while also showing uniform zero background when imaging using cross-polarised light. This makes it our most advanced polymer to date.

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UVXPO Sealing Sheets

Sealing Sheets, Crystallisation, UVXPO

UVXPO Sealing Sheets

SWISSCI’s UVXPO Sealing sheets are a 50 µm film with 50 µm inert encapsulated silicone adhesive. They are optically clear, with minimal to no auto-fluorescence (UV compatible), and are especially suited for protein crystallization and qPCR applications.

The encapsulated silicone adhesive is non-tacky until pressed against the sealing surface, at which time adhesive is released only in sealing areas to form the strongest available heat-resistant seal around each well on the plate. The adhesive on non-sealing areas of the film, such as directly over sample wells, remains encapsulated and inert.

UVXPO Sealing sheets are sized to fit within the edges of SWISSCI plates. Two end tabs assist in positioning the film on the plate, and the non-tacky adhesive surface simplifies handling. Easy removal of the end tabs at perforated boundaries prevents lifting and higher evaporation rates that can occur with films that overlap the plate rim.

· High optical clarity
· Minimal to no auto-fluorescence (UV compatible)
· Chemically inert; no extractables except at extreme pH
· DMSO resistant for HTS
· Heat resistant recommended for temperatures from -70 °C to +105 °C
· Certified DNase-, RNase-, and nucleic-acid-free
· Silicone adhesive forms the strongest available seal for evaporation prevention
· Non-tacky adhesive layer simplifies handling of the film prior to sealing

Order Details:
UVXPO Sealing sheets – Box of 100 – Code: UVXPO-SEAL

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SWISSCI Cryo-EM Grid Box

Cryo-EM, Grid Box

Cryo EM Grid Box for Transfer and Storage of Vitrified Samples

Grid boxes form an essential part of the Cryo EM workflow as they enable the transfer and storage of vitrified samples on standard EM grids in liquid nitrogen storage dewars. The SWISSCI Cryo EM Grid Box has been specially developed to improve on many features of current solutions. the SWISSCI Cryo EM Grid Box has been developed in close collaboration with the MRC Laboratory of Molecular Biology in Cambridge.

The SWISSCI Cryo EM Grid Box is made from a special polymer formulation for zero static at cryogenic temperatures. The box has four diamond-shaped slot positions with identification numbers. No special tools are required since the lid is rotated with standard laboratory tweezers. The Cryo EM Grid Box is of standard size for all common Cryo EM sample mounting and storage devices.

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SWISSCI XPOL LCP for Excellent Crystal Viewing

XPOL, Crystallisation, LCP, Sealing Sheets

SWISSCI XPOL LCP

The new SWISSCI XPol LCP allows excellent crystal viewing for even the smallest of crystals, with uniform zero background when using cross polarised light.

The SWISSCI XPol LCP was developed closely with the Protein Crystallisation Center of the University of Zurich. The center has many years of expertise in crystallizing membrane proteins. The XPol LCP kit has been specially formulated to improve performance versus standard LCP systems.

The Hydrophobic (silanized) Glass Base comes in ANSI/SLAS 1-2004-Standard (SBS) format allowing for easy automation and high throughput screening. The Double-Sided Pressure Adhesive, available in 60μm and 120μm, comes readily stuck to the Glass Base with space for barcode application. The Double-Sided Pressure Adhesive has 96 holes which are 7mm in diameter and have a 2.3μ volume in the 60μm version and 4.6μl volume for 120μm. The large diameter almost eliminates the occurrence of precipitation solution being pulled to the side, which can often happen with smaller diameter holes.

The SWISSCI XPol LCP comes as standard with 175μm Cover Glass. For the addition of UV/Flu, UV Cover Films are also available upon request at 40μm, 100μm or 200μm thickness.

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LCP Pressure Adhesives and Sealing Paddles

Sealing Paddles, LCP, Pressure Adhesives

LCP Double-sided Adhesive Seals

Various double-sided adhesive seals for 96 well products are available to order in packs of 10:

200μm Seal 5.5mm Hole / Pack of 10 / Code 010702
100μm Seal 5.5mm Hole / Pack of 10/ Code 010701
50μmSeal 5.5mm Hole / Pack of 10/ Code 010700
50μm Seal 7.0mm Hole / Pack of 10/ Code 010707

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