SWISSMX CM Supports

Crystallisation, Supports
swissmxcm supports
SWISSMX CM Supports - Image 2
SWISSMX CM Supports - Image 3
SWISSMX CM Supports - Image 4
SWISSMX CM Supports - Image 5

SWISSCMX CM Supports are an innovative support for serial data collection from micro-crystals

The SWISSMX CM supports are designed for high throughput serial data collection from micro-crystals at synchrotrons and XFELS. SWISSMX CMs are designed and engineered by scientists of the Macromolecular Crystallography group and the Laboratory of  Micro and Nanotechnology at the Paul Scherrer Institute in collaboration with the Institute of Polymer Nanotechnology at Fachhochschule Nordwestschweiz.  The polymer-based ultra-thin porous membranes present users with an effective and accessible product for use at MX beamlines.

SWISSMX CM Supports Low Background Ultra Thin Porous Membranes

  • Amorphous COC (Cyclic Olefin Copolymer) for low X-ray scattering
  • Microfabricated film with imprinted perforations

Blotting Function

  • Easy deposition of drop-scale samples
  • Efficient blotting to minimize background
  • Hydrophilic surface properties help to retain a thin hydration film around the crystals

Designed to be used at cryogenic temperatures

  • Dimensions designed for fitting in standard (cryo)streams
  • Flash-cooling possible in cryojet or liquid nitrogen
  • Room temperature use possible: compatible with humidifying jets, enclosure possible

Extensive Compatibility

  • SPINE base or ALS style base
  • Compatible with Uni-puck and with SPINE pucks (cryovial)
  • Compatible with a number of sample changers including the new TELL at Swiss Light Source and SwissFEL SwissMX

Additional Benefits

  • High transparency for excellent visibility and imaging
  • Built-in 100 µm period scale

Link to a publication detailing the fabrication of SWISSMXCM Supports: https://www.sciencedirect.com/science/article/pii/S2590007220300083

 

Contact: sales@swissci.com

 
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SWISSCI Plates: Improvements in Imaging with UVXPO

UVXPO, Crystallisation, Midi UVXPO

UVXPO: Our Most Advanced Polymer

SWISSCI crystallisation plates are available in 3 polymers.  Polystyrene (PS) is a cost-effective polymer that Is optically clear when using standard bright field or visible light sources. However, when imaging drops using both cross polarised (XP) and UV light, the quality of the image is impaired by the interaction of the polymer with the light source.

SWISSCI’s UVP polymer has been designed to reduce the auto-fluorescence coming from the plate, improving the UV image quality. 

SWISSCI’s UVXPO polymer also has the same low auto-fluorescence while also showing uniform zero background when imaging using cross-polarised light. This makes it our most advanced polymer to date.


More information:
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UVXPO Sealing Sheets

Sealing Sheets, Crystallisation, UVXPO
UVXPO SEALING SHEET
UVXPO Sealing Sheets - Image 2
2 Lens

UVXPO Sealing Sheets

SWISSCI’s UVXPO Sealing sheets are a 50 µm film with 50 µm inert encapsulated silicone adhesive. They are optically clear, with minimal to no auto-fluorescence (UV compatible), and are especially suited for protein crystallization and qPCR applications.

​The encapsulated silicone adhesive is non-tacky until pressed against the sealing surface, at which time adhesive is released only in sealing areas to form the strongest available heat-resistant seal around each well on the plate. The adhesive on non-sealing areas of the film, such as directly over sample wells, remains encapsulated and inert.

UVXPO Sealing sheets are sized to fit within the edges of  SWISSCI plates. Two end tabs assist in positioning the film on the plate, and the non-tacky adhesive surface simplifies handling. Easy removal of the end tabs at perforated boundaries prevents lifting and higher evaporation rates that can occur with films that overlap the plate rim.

· High optical clarity
· Minimal to no auto-fluorescence (UV compatible)
· Chemically inert; no extractables except at extreme pH
· DMSO resistant for HTS
· Heat resistant recommended for temperatures from -70 °C to +105 °C
· Certified DNase-, RNase-, and nucleic-acid-free
· Silicone adhesive forms the strongest available seal for evaporation prevention
· Non-tacky adhesive layer simplifies handling of the film prior to sealing

Order Details:
UVXPO Sealing sheets – Box of 100 –  Code:  UVXPO-SEAL

More information:
sales@swissci.com

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SWISSCI XPOL LCP for Excellent Crystal Viewing

XPOL, Crystallisation, LCP, Sealing Sheets

SWISSCI  XPOL LCP

The new SWISSCI XPol LCP allows excellent crystal viewing for even the smallest of crystals, with uniform zero background when using cross polarised light.

The SWISSCI XPol LCP was developed closely with the Protein Crystallisation Center of the University of Zurich. The center has many years of expertise in crystallizing membrane proteins. The XPol LCP kit has been specially formulated to improve performance versus standard LCP systems.

The Hydrophobic (silanized) Glass Base comes in ANSI/SLAS 1-2004-Standard (SBS) format allowing for easy automation and high throughput screening. The Double-Sided Pressure Adhesive, available in 60μm and 120μm, comes readily stuck to the Glass Base with space for barcode application. The Double-Sided Pressure Adhesive has 96 holes which are 7mm in diameter and have a 2.3μ volume in the 60μm version and 4.6μl volume for 120μm. The large diameter almost eliminates the occurrence of precipitation solution being pulled to the side, which can often happen with smaller diameter holes.

The SWISSCI XPol LCP comes as standard with 175μm Cover Glass. For the addition of UV/Flu, UV Cover Films are also available upon request at 40μm, 100μm or 200μm thickness.

 

More information:
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SWISSCI 3-Lens Midi UVXPO Plate

3-Lens, Midi UVXPO

3 Lens Crystallisation Plate
3 Lens Low Profile Crystallisation late
3 Lens Crystallisation Plate - Image 3

SWISSCI 3-Lens Midi UVXPO Plate

After great success with the launch of the 2-Lens UVXPO Plate, SWISSCI are pleased to announce our 3-Lens Midi Plates are now also available in UVXPO, Product

Code: UVXPO-3LENS.

UVXPO is a new polymer mixture specially formulated so that crystals can be viewed in UV, Polar, and Visible light. UVXPO is short for UV compatible as well as excelling uniform (zero) background when using cross polarised light.

More information:
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SWISSCI LCP Modular

LCP, Crystallisation, Pressure Adhesives, Sealing Sheets

LCP Modular range
XPol LCP Lipid Cubic Phase
Sealing Paddle

SWISSCI LCP Modular

The SWISSCI LCP Modular range aims to offer more flexibility to the membrane protein crystallographers LCP experiment. There are three choices of LCP Bases which are combined with one of five pre-affixed LCP Double Sided Pressure Adhesives*. The Pressure Adhesives are of varying thickness and well dimensions. To complete the LCP sandwich plate there is a choice between two sizes of Cover Glass or three UVP Cover Films that are of varying thickness.

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LCP Sandwich Options:

LCP Bases: SBS XPOL Glass Base, Glass Base and UVXPO Plastic Base​

Spacers: 60 μm, 100 μm, 120 μm, 200 μm. Well sizes: 5.5 mm and 7 mm.

Covers: Cover Glass, Large Cover Glass, 40 μm Cover Film, 100 μm Cover Film, 200 μm Cover film covers

White PS tray for Automation:  low tack or no tack

* Separated bases and adhesives available on request

Order Details

UVXPO Sealing sheets – Box of 100 C
Code:  UVXPO-SEAL

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Data Sheet

"SWISSCI LCP Modular system has made us more productive and efficient with better results."

– Customer

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Tel: +44 (0)1932 481 444

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