NPL and SWISSCI complete a successful Measurement for Recovery (M4R) project

NPL and SWISSCI complete a successful Measurement for Recovery (M4R) project with breakthrough results in crystallisation.

SWISSCI in collaboration with Dr Isabel Moraes, a Principal Research Scientist from NPL, have recently completed a successful M4R project to explore dialysis as an alternative method to established high throughput protein crystallography methodologies.

Using the Diaplate™, a SWISSCI manufactured 96 well high throughput dialysis plate, the NPL science team were able to demonstrate dialysis as a reliable high-throughput method for macro-molecular crystallisation by successfully crystallising 4 different proteins, including 2 membrane proteins.

The membrane proteins crystallised four-fold faster than using any other technique and produced high quality crystals. This data suggests that high-throughput dialysis may have some distinct advantages over other methods and is very simple to employ.

Tristan Kwan of NPL, who performed many of the experiments commented

“Accelerated crystal growth was among some interesting findings and a very welcome surprise. We will employ the technique to expand on the range of crystallisation methods we use in the lab”.

For all the proteins tested, the team were able to grow a high density of microcrystals in certain conditions. Furthermore, the yield of crystals was able to be increased by scaling up the experiment using a higher volume, standalone, SWISSCI manufactured dialysis device, the Diacon™.


The results of these experiments indicate that dialysis is an effective method for high throughput protein crystallography and it can be considered as a viable complementary method to the established crystallisation technologies. Initial findings also indicate that it could be a method of choice for production of micro/nano crystals for modern data collection methods including serial crystallography at microfocus beamlines / XFEL’s and MicroED.


An innovative support for serial data collection from micro-crystals

The SWISSMX CM supports are designed for high throughput serial data collection from micro-crystals at synchrotrons and XFELS. SWISSMX CMs are designed and engineered by scientists of the Macromolecular Crystallography group and the Laboratory of  Micro and Nanotechnology at the Paul Scherrer Institute in collaboration with the Institute of Polymer Nanotechnology at Fachhochschule Nordwestschweiz.  The polymer-based ultra-thin porous membranes present users with an effective and accessible product for use at MX beamlines.

Low Background Ultra Thin Porous Membranes

  • Amorphous COC (Cyclic Olefin Copolymer) for low X-ray scattering
  • Microfabricated film with imprinted perforations

Blotting Function

  • Easy deposition of drop-scale samples
  • Efficient blotting to minimize background
  • Hydrophilic surface properties help to retain a thin hydration film around the crystals

Designed to be used at cryogenic temperatures

  • Dimensions designed for fitting in standard (cryo)streams
  • Flash-cooling possible in cryojet or liquid nitrogen
  • Room temperature use possible: compatible with humidifying jets, enclosure possible

Extensive Compatibility

  • SPINE base or ALS style base
  • Compatible with Uni-puck and with SPINE pucks (cryovial)
  • Compatible with a number of sample changers including the new TELL at Swiss Light Source and SwissFEL SwissMX

Additional Benefits

  • High transparency for excellent visibility and imaging
  • Built-in 100 µm period scale

Link to a publication detailing the fabrication of SWISSMXCM Supports:




SWISSCI Plates: Improvements in Imaging with UVXPO

UVXPO: Our Most Advanced Polymer

SWISSCI crystallisation plates are available in 3 polymers.  Polystyrene (PS) is a cost-effective polymer that Is optically clear when using standard bright field or visible light sources. However, when imaging drops using both cross polarised (XP) and UV light, the quality of the image is impaired by the interaction of the polymer with the light source.

SWISSCI’s UVP polymer has been designed to reduce the auto-fluorescence coming from the plate, improving the UV image quality. 

SWISSCI’s UVXPO polymer also has the same low auto-fluorescence while also showing uniform zero background when imaging using cross-polarised light. This makes it our most advanced polymer to date.

More information:

SWISSCI Product Catalog

SWISSCI Consumables Product Catalog.

We continue to innovate and expand our product range through collaboration. New products will be announced as we bring them to market.

We welcome requests for product innovation ideas. If you have an unmet need, please contact our team to discuss new project proposals:

UVXPO Sealing Sheets

UVXPO Sealing Sheets

SWISSCI’s UVXPO Sealing sheets are a 50 µm film with 50 µm inert encapsulated silicone adhesive. They are optically clear, with minimal to no auto-fluorescence (UV compatible), and are especially suited for protein crystallization and qPCR applications.

The encapsulated silicone adhesive is non-tacky until pressed against the sealing surface, at which time adhesive is released only in sealing areas to form the strongest available heat-resistant seal around each well on the plate. The adhesive on non-sealing areas of the film, such as directly over sample wells, remains encapsulated and inert.

UVXPO Sealing sheets are sized to fit within the edges of  SWISSCI plates. Two end tabs assist in positioning the film on the plate, and the non-tacky adhesive surface simplifies handling. Easy removal of the end tabs at perforated boundaries prevents lifting and higher evaporation rates that can occur with films that overlap the plate rim.

· High optical clarity
· Minimal to no auto-fluorescence (UV compatible)
· Chemically inert; no extractables except at extreme pH
· DMSO resistant for HTS
· Heat resistant recommended for temperatures from -70 °C to +105 °C
· Certified DNase-, RNase-, and nucleic-acid-free
· Silicone adhesive forms the strongest available seal for evaporation prevention
· Non-tacky adhesive layer simplifies handling of the film prior to sealing

Order Details:
UVXPO Sealing sheets – Box of 100 –  Code:  UVXPO-SEAL

More information:

SWISSCI Cryo-EM Grid Box

Cryo EM Grid Box for Transfer and Storage of Vitrified Samples

Grid boxes form an essential part of the Cryo EM workflow as they enable the transfer and storage of vitrified samples on standard EM grids in liquid nitrogen storage dewars. The SWISSCI Cryo EM Grid Box has been specially developed to improve on many features of current solutions. the SWISSCI Cryo EM Grid Box has been developed in close collaboration with the MRC Laboratory of Molecular Biology in Cambridge.

The SWISSCI Cryo EM Grid Box is made from a special polymer formulation for zero static at cryogenic temperatures. The box has four diamond-shaped slot positions with identification numbers. No special tools are required since the lid is rotated with standard laboratory tweezers. Uniquely numbered Pressure Adhesive Cryo Labels are supplied with the boxes. The Cryo EM Grid Box is of standard size for all common Cryo EM sample mounting and storage devices.

More information:

SWISSCI XPOL LCP for Excellent Crystal Viewing


The new SWISSCI XPol LCP allows excellent crystal viewing for even the smallest of crystals, with uniform zero background when using cross polarised light.

The SWISSCI XPol LCP was developed closely with the Protein Crystallisation Center of the University of Zurich. The center has many years of expertise in crystallizing membrane proteins. The XPol LCP kit has been specially formulated to improve performance versus standard LCP systems.

The Hydrophobic (silanized) Glass Base comes in ANSI/SLAS 1-2004-Standard (SBS) format allowing for easy automation and high throughput screening. The Double-Sided Pressure Adhesive, available in 60μm and 120μm, comes readily stuck to the Glass Base with space for barcode application. The Double-Sided Pressure Adhesive has 96 holes which are 7mm in diameter and have a 2.3μ volume in the 60μm version and 4.6μl volume for 120μm. The large diameter almost eliminates the occurrence of precipitation solution being pulled to the side, which can often happen with smaller diameter holes.

The SWISSCI XPol LCP comes as standard with 175μm Cover Glass. For the addition of UV/Flu, UV Cover Films are also available upon request at 40μm, 100μm or 200μm thickness.


More information:

LCP Pressure Adhesives and Sealing Paddles

LCP Double-sided Adhesive Seals

Various double-sided adhesive seals for 96 well products are available to order in packs of 10:​​​

200μm Seal 5.5mm Hole / Pack of 10 / Code 010702
100μm Seal 5.5mm Hole / Pack of 10/ Code 010701
50μmSeal 5.5mm Hole / Pack of 10/ Code 010700
50μm Seal 7.0mm Hole / Pack of 10/ Code 010707

More information:

SWISSCI 3-Lens Midi UVXPO Plate

SWISSCI 3-Lens Midi UVXPO Plate

After great success with the launch of the 2-Lens UVXPO Plate, SWISSCI are pleased to announce our 3-Lens Midi Plates are now also available in UVXPO, Product


UVXPO is a new polymer mixture specially formulated so that crystals can be viewed in UV, Polar, and Visible light. UVXPO is short for UV compatible as well as excelling uniform (zero) background when using cross polarised light.

More information:

New Ultrafiltration and Dialysis Product Range

Ultrafiltration and Dialysis Product Range


SWISSCI is pleased to announce the new Ultrafiltration and Dialysis Range. The Ultrafiltration Range include 0.5ml, 6ml, 15ml, and 20ml capacity dialyzers. The Dialysis Range include 3.2µl, 0.5ml, and 20ml capacity dialyzers.

More information:

Glass Bottom Optical Plates for Imaging

SWISSCI Glass Bottom Assay Plates

SWISSCI Glass Bottom (GB) plates are a new benchmark in micro-plate technology. The unique SWISSCI glass plate processing technique reduces autofluorescence to less than 5 percent of the level for unprocessed plates and generates a higher signal-to-noise ratio. SWISSCI glass-bottom plates are also available in 96, 384, and 1536 well formats.



Reliable performance
Overall microplate flatness (planarity) guarantees a lower error ratio across the focal plane.

Increased working volume
Square well is ideal for high-throughput operations and delivers maximum volume.

Low-base design
The low-base design ensures the readability of all wells, including outer wells.

Multiple Applications
Including: Fluorescence correlation spectroscopy (FCS); Confocal imaging; Fluorescence Polarisation (FP); Cell-based assays; Cell culture.

Low auto-fluorescence
Special, high-quality glass provides a lower fluorescent background and higher signal-to-noise ratio essential in all fluorescence applications.

More information:

JANSi Instrumentation

JANSi UVEX Imaging Systems

SWISSCI and JAN Scientific have partnered to bring the UVEX crystal imaging systems to the market. With over 100 installations around the world, the UVEX is rapidly becoming the crystallographer’s go-to tool for the rapid detection and intuitive classification of protein crystals.

Key Features:

• Cooled, high-efficiency 6 MP monochrome UV camera.
• LED light sources, low maintenance, and long-lasting.
• Detect Protein crystals with ease. Detect micro-crystals hidden in the precipitate.
• Powerful imaging of protein crystals in LCP.  
• An industry-leading resolution of 0.2 micron/pixel with optional objectives• UV excitation/emission optimized for Trp fluorescence.
• Intuitive software with image management.
• Z slicing to produce a composite, extended depth image.
• Automatic drop centering with manual override (available on the UVEXp + UVEXps models).
• Autofocus (available on the UVEXp + UVEXps models).
• Standalone UVEX-p can be retrofitted into our plate hotels with a huge cost saving (available on the UVEXp + UVEXps models).
• Various options available including; Colour bi-refringence, UV absorbance, additional objectives. 

UVEX Imaging Models


Includes: Tray table,  5X and 15X objectives, brightfield and UV imaging, Computer , monitor and all software
Options: Motorized Z, Manual X/Y stage, additional objectives, UV absorbance, cross-polarisers.
Dimensions: : 30 x 20 x50 cm  Weight: 12 kg
Power:  110-240 V 50 Hz/60 Hz 60 kWh

More information:


Includes: Automated imaging crystallisation plates, extended depth imaging, Drop find, Autofocus, 5X, 10X (or15X) and 20X objectives, all software, computer and monitor,
Options: additional objectives, UV absorbance, colour cross-polarisers.
Dimensions: 30 x 35 x50 cm  Weight: 16 kg
Power: : 110-240 V 50 Hz/60 Hz 120kWh

More information:

UVEXps 256 /600

Includes: UVEXp, Smooth low-vibration operation to move plates, Built-in sensors to monitor the status of a plate, Collision detection and recovery, Built-in barcode scanner, configurable storage shelves for standard and low, high-profile or LCP SBS plates, Shelf capacity can be changed in field (some restrictions apply), Built in IR cameras ,  Barcode printer with 4000 labels
Options: Temperature control 4 – 25 C (*available for UVEXps256) – Peltier temperature regulation (available for both hotel models).
Dimensions: UVEX256 : w90 x d72 x h212 cm UVEXps600: w90 x d95 x h212 cm
Weight: 350 and 450 kg
Power: 110-240 V 50 Hz/60 Hz 0.5 kWh

More information:



The SWISSCI LCP Modular range aims to offer more flexibility to the membrane protein crystallographers LCP experiment. There are three choices of LCP Bases which are combined with one of five pre-affixed LCP Double Sided Pressure Adhesives*. The Pressure Adhesives are of varying thickness and well dimensions. To complete the LCP sandwich plate there is a choice between two sizes of Cover Glass or three UVP Cover Films that are of varying thickness.

LCP Sandwich Options:

LCP Bases: SBS XPOL Glass Base, Glass Base and UVXPO Plastic Base

Spacers: 60 μm, 100 μm, 120 μm, 200 μm. Well sizes: 5.5 mm and 7 mm.

Covers: Cover Glass, Large Cover Glass, 40 μm Cover Film, 100 μm Cover Film, 200 μm Cover film covers

White PS tray for Automation:  low tack or no tack

* Separated bases and adhesives available on request

Order Details

UVXPO Sealing sheets – Box of 100 C

Download Data Sheet

"SWISSCI LCP Modular system has made us more productive and efficient with better results."

– Customer

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